What Does Lupron Do to Your Body?

Summary. Lupron is a type of hormone therapy for prostate cancer. It works by lowering the amount of testosterone in a person’s body, which helps slow the growth of cancer cells. Doctors often prescribe hormone therapies in combination with radiation therapy or following surgery.

Can Lupron kill you?

Those reports frequently note injection-site pain but also include dozens of cases of bone problems, such as pain or disorders, and the inability to walk. Among men who take Lupron, its label warns of increased risk of heart attacks, strokes and sudden death.

What are the long term side effects of Lupron?

Nearly half (45%) of subjects reported side effects that they considered to be “irreversible,” including bone density loss, memory loss, decreased libido, insomnia, anxiety, hypertension, hot flashes, headache, acne, trouble sleeping, nerve pain, joint pain, and weight gain.

How long does it take for Lupron to wear off?

The effects of Leuprolide acetate will decrease after you stop taking the medicine. If you’ve been getting Lupron® every 3 months, your period will usually return within 4 to 8 months after your last shot.

Does Lupron make you emotional?

Lupron, a GnRH agonist, is one of the best known and most hated of IVF treatment injectable fertility drugs. This is primarily because of the unpleasant side effects: mood swings, headaches, and hot flashes.

Does Lupron make you hungry?

unusual changes in mood or behavior (crying spells, anger, feeling irritable); sudden chest pain or discomfort, wheezing, dry cough or hack; painful or difficult urination; or. high blood sugar–increased thirst, increased urination, hunger, dry mouth, fruity breath odor.

Can you lose weight while on Lupron?

Weight changes may occur with Lupron Depot use. One of the most common side effects of women taking Lupron Depot is weight gain. However, some women may experience weight loss instead.

Does Lupron shot cause weight gain?

The most common side effects of LUPRON DEPOT included hot flashes/sweats, headache/migraine, decreased libido (interest in sex), depression/emotional lability (changes in mood), dizziness, nausea/vomiting, pain, vaginitis, and weight gain. These are not all of the possible side effects of LUPRON DEPOT.

Does Lupron affect memory?

For many of you, it’s the hormone therapies that cause the hardest mental challenges. These therapies range from the Lupron (Leuprolide injection) to androgen deprivation therapy (ADT). “I’ve been looking deeper into my continuing nemesis, Lupron. It can cause depression and ‘memory problems’.

How bad is Lupron?

The FDA currently has over 25,000 adverse event reports for Lupron products including more than 1500 deaths. Reactions include suicidal thoughts, stroke, muscle atrophy and debilitating bone and joint pain.

Can Lupron cause a stroke?

High blood sugar and increased risk of diabetes can occur in men using LUPRON DEPOT. (Your doctor will monitor your blood sugar during treatment). An increased risk of heart attack, sudden death, and stroke can also occur.

Is Lupron considered chemotherapy?

Lupron is not cytotoxic chemotherapy. It is a hormone modulating drug that ultimately drops estrogen and testosterone levels in the body. While this may be useful in some cancers, it is not really chemotherapy.

Does Lupron suppress immune system?

Lupron (leuprolide) is a hormone treatment that reduces levels of testosterone, which slows the growth of prostate cancer. Atezolizumab is a type of drug called a PD-L1 blocker; it blocks a protein located on the surface of some tumor cells and immune cells that can act as a “brake” on the immune system.

When does testosterone return after Lupron?

Conclusion: After LHRHa treatment and radiotherapy, the testosterone levels of most men had recovered to normal by 18-24 weeks after the last LHRHa injection.

Why is there a Lupron shortage?

Reason for the Shortage Abbvie states Lupron Depot was on shortage due to a routine manufacturing compliance review.

Is there an alternative to Lupron?

Examples of other drugs that may be used for palliative treatment of advanced prostate cancer include: leuprolide (Eligard, Lupron Depot) goserelin (Zoladex) degarelix (Firmagon)

Is Lupron discontinued?

LUPRON is indicated for palliative treatment of advanced prostatic cancer. LUPRON (leuprolide acetate) injection, 1 mg/0.2 mL, is currently listed in the “Discontinued Drug Product List” section of the Orange Book.

What are side effects of Lupron?

Mild burning/pain/bruising at the injection site, hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal discomfort/dryness, vaginal bleeding, swelling of the ankles/feet, increased …

What should I expect after my first Lupron shot?

When you first begin treatment with Lupron, the estrogen levels in your body increase for 1 or 2 weeks. Some women experience a worsening of their symptoms during this time. After a few weeks, your estrogen levels will decrease, stopping ovulation and your period.

What drugs interact with Lupron?

View interaction reports for Lupron (leuprolide) and the medicines listed below.




Aspirin Low Strength (aspirin)



Casodex (bicalutamide)

Flomax (tamsulosin)

Where is Lupron injected?

Here are step-by-step instructions for taking Lupron® (leuprolide acetate) injections: Lupron® is injected subcutaneously-or into the fatty tissue under your skin. The primary sites for injection are your abdomen – 2 inches on either side of the navel;- and your upper, outer-thigh where the skin is loose.

How much does Lupron cost?

Learn more about this drug here. This is a brand name drug and a generic may be available. The average cost for 1 Kit, 3.75mg each, is $1675.07. You can buy Lupron Depot (1-Month) at the discounted price of $1393.33 by using the WebMDRx coupon, a savings of 17%.

What time of day should I take Lupron?

SUBCUTANEOUS INJECTION 1. Give injections same time every day (morning or evening). Some protocols for selective responders may require morning and evening injections.

Are Lupron side effects reversible?

Lupron Depot side effects are almost always reversible and will go away after treatment is complete. There are many options to help minimize or prevent Lupron Depot side effects.

Can you still get your period on Lupron?

When this medication is used regularly, it is expected that the menstrual period will stop (or decrease to light bleeding/spotting). Menstrual periods usually return within 3 months after treatment is stopped. Tell your doctor promptly if regular periods continue during treatment with leuprolide.

Can Lupron cause permanent menopause?

Lupron lowers estrogen levels in the body, typically triggering menopause-like symptoms. According to the manufacturer’s clinical trials, 74% of participants who took Lupron stopped having their periods after the first month of treatment, and menstruation ceased in 98% of this group after 2 months.

How long does Lupron Depot Take to shrink fibroids?

How well does Lupron Depot work? Studies have shown women with endometriosis who have menstrual pain/cramping found relief about 96% of the time. Women with pelvic pain found relief about 53% of the time. Fibroids can shrink a maximum of 30% to 50% in volume within 2 to 3 months of treatment.

Can you still ovulate on Lupron?

Ovulation cannot occur naturally while on Lupron because LH, which triggers ovulation, is suppressed. This prevents a premature surge of the LH before the retrieval, which could cause loss of the cycle. Once the eggs are mature, an injection of Human chorionic gonadotropin (hCG) or LH is given to stimulate ovulation.

Does Lupron improve egg quality?

Lupron is also used in I.V.F. cycles to improve the number and quality of eggs available for fertilization and in Egg Donation I.V.F. and Frozen Embryo Transfer to prepare the uterine lining (endometrium) for embryo transfer.

What happens if I get pregnant while on Lupron?

The possibility exists that spontaneous abortion may occur if the drug is taken during pregnancy. Patients should use a non-hormonal method of contraception. If you become pregnant while using Lupron Depot, tell your doctor immediately. If you become pregnant, your doctor will stop your treatment.